Recombinant human Bridge-like lipid transfer protein family member 2 (BLTP2) fragment (residues 1750-2029) is a high-quality protein product designed for structural and biochemical studies. This 280-amino acid fragment, computationally selected for stability and solubility, enables researchers to investigate the lipid transport functions of BLTP2 in a manageable and functional format.

Bridge-like lipid transfer protein family member 2 (BLTP2) is a tube-forming lipid transport protein that specifically binds to phosphatidylinositols and modulates the distribution of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2), playing a crucial role in cellular lipid homeostasis. The protein localizes to multiple membrane compartments, including the cell membrane, endoplasmic reticulum membrane, and mitochondrial membrane, where it facilitates lipid transfer at membrane contact sites such as endoplasmic reticulum-cell membrane and endoplasmic reticulum-mitochondria interfaces. This strategic localization underscores its importance in inter-organelle lipid trafficking and membrane dynamics.