Budesonide Monoclonal Antibody

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  • 抗体类型:单克隆
  • 抗体来源:
  • 抗体应用:ELISA
  • 特异性:Chemical

产品详情

  • 产品名称
    Budesonide Monoclonal Antibody
  • 抗体类型
    单克隆
  • 抗体亚型
    Mouse IgG1, κ
  • 抗体描述
    Product has been tested in direct ELISA.
  • 抗体应用
    ELISA
  • 应用推荐
    ELISA: 1:5,000-1:20,000
  • 特异性
    Chemical
  • 制备方法
    Budesonide conjugated with BSA. Protein G affinity purified
  • 组分
    PBS(pH7.4), lyophilized. Reconstitution: Adding sterile water, prepare a stock solution of 2.0 mg/ml.
  • 储存方法
    Store at -20℃. Avoid freeze / thaw cycles.
  • 背景介绍
    Budesonide is a potent corticosteroid medication renowned for its efficacy in managing inflammatory diseases affecting both the airways and gastrointestinal tract. This glucocorticoid exerts its therapeutic effects primarily through topical administration, demonstrating a remarkable ability to alleviate symptoms with less impact on the hypothalamic-pituitary-adrenal axis compared to equivalent doses of oral prednisone. Beyond its traditional uses, budesonide has also found application as a payload in antibody–drug conjugates, underscoring its versatility in combating inflammatory conditions and even cancer. By binding to glucocorticoid receptors, budesonide initiates cascades of gene expression changes that modulate inflammation over varying time frames, making it a cornerstone in the treatment of diverse inflammatory disorders.
  • 参考文献
    • Yasir M, Goyal A, Sonthalia S. Corticosteroid Adverse Effects. 2023 Jul 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30285357.
    • Gardill BR, Vogl MR, Lin HY, Hammond GL, Muller YA. Corticosteroid-binding globulin: structure-function implications from species differences. PLoS One. 2012;7(12):e52759. doi: 10.1371/journal.pone.0052759. Epub 2012 Dec 26. PMID: 23300763; PMCID: PMC3530532.
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