Derived from buforin I after treatment with endoproteinase Lys-C. It displayed a more potent antimicrobial activity than its parent molecule. In TFE, buforin II contains a helix-hinge-helix structure with the first 4 aa disordered. A proline connects helix 1 (residues 5-10) and helix 2 (residues 12-21). MOA: It kills bacteria without lysing the cell. Instead, this peptide translocates aross bacterial membranes effectively. This is a typical peptide example that does not target bacterial membranes but internal targets such as nucleic acids. It has a strong affinity for DNA and RNA in vitro (Park et al 1998. Biochem Biophys Res Commun 244: 253-7). Both buforin II and its derivative buforin IIb (sequence: RAGLQFPVGRLLRRLLRRLLR) showed selective anticancer activity against 62 cancer cell lines (Lee 2008 Cancer Lett 271: 47-51). The sequence of histonin is RAGLQFPVGKLLKKLLKRLKR (updated 12/2008; Jan2013). Buforin II has Antibacterial, Antifungal activity. The source of Buforin II is Bufo bufo gargarizans, Asia.
储存指南
一般情况下, Buforin II 多肽 粉末应该保存在-20甚至-70摄氏度. Buforin II 多肽 溶解后应该-70摄氏度分装保存,避免反复冻融. 了解更多细节,请查阅手册:多肽溶解及保存指南