- 序列:{Eicosanedioic-acid-γ-Glu}-KCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP-NH2 (Disulfide bridge:C3-C8)
- 分子式:C194H312N54O59S2
相关文档
批次之间数据可能略有差异
产品详情
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产品名称
Cagrilintide, 98.66% purity 多肽 (TFA已除)
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序列
{Eicosanedioic-acid-γ-Glu}-KCNTATCATQRLAEFLRHSSNNFGPILPPTNVGSNTP-NH2 (Disulfide bridge:C3-C8)
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三字母序列
{Eicosanedioic-acid-γ-Glu}-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Pro-NH2 (Disulfide bridge:Cys3-Cys8)
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长度 (aa)
39
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多肽纯度 (HPLC, %)
98.66
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分子式
C194H312N54O59S2
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分子量(Da)
4409.01
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CAS No.
1415456-99-3
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PubChem CID
167312356
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来源
固相合成
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描述
Cagrilintide is a non-selective AMYR/CTR agonist and long-acting acylated amylase analogue. CagriSema is combined with Cagrilintide and Semaglutide. The clinical phase II trial of CagriSema in diabetic patients was successfully completed with superior weight loss and glucose-lowering effects compared to simethicone. The trial included 92 patients with type 2 diabetes with overweight, randomized equally into 3 groups: CagriSema injection (2.4 mg of simeplutide and 2.4 mg of cagrilintide), 2.4 mg of simeplutide alone, and 2.4 mg of cagrilintide alone. the treatment duration was 32 weeks, and subjects had a mean baseline HbA1c was 8.4% and mean baseline weight was 106 kg. The results showed that in terms of weight loss, CagriSema injection significantly outperformed simepaglutide (5.1%) and cagrilintide (8.1%) by 15.6% of body weight loss.
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储存指南
一般情况下, Cagrilintide, 98.66% purity 多肽 (TFA已除) 粉末应该保存在-20甚至-70摄氏度. Cagrilintide, 98.66% purity 多肽 (TFA已除) 溶解后应该-70摄氏度分装保存,避免反复冻融. 了解更多细节,请查阅手册:多肽溶解及保存指南
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参考文献
- Kruse T, Hansen JL, Dahl K, et al. Development of Cagrilintide, a Long-Acting Amylin Analogue. J Med Chem. 2021;64(15):11183-11194. doi:10.1021/acs.jmedchem.1c00565
- Dehestani B, Stratford NR, le Roux CW. Amylin as a Future Obesity Treatment. J Obes Metab Syndr. 2021;30(4):320-325. doi:10.7570/jomes21071
- Fletcher MM, Keov P, Truong TT, et al. AM833 Is a Novel Agonist of Calcitonin Family G Protein-Coupled Receptors: Pharmacological Comparison with Six Selective and Nonselective Agonists. J Pharmacol Exp Ther. 2021;377(3):417-440. doi:10.1124/jpet.121.000567
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关于三氟乙酸盐
三氟乙酸(TFA)是一种强酸,常用于从固相树脂中裂解合成的多肽,也可用于提高多肽纯化步骤中的HPLC性能。默认情况下,定制的多肽是以冻干的TFA盐的形式交付的,其中TFA的含量可能高达10-45%。
定制多肽中的TFA可能会导致后续检测数据出现无法解释的差异。例如,nM浓度的TFA已被证明会干扰细胞实验,在某些情况下会抑制细胞增殖,而在其他情况下会增加细胞活力。
TFA去除服务推荐用于:
- 将用于细胞试验的多肽
- 将被用作原料药或制成品的多肽
- 含有大量碱性残基的亲水多肽
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关于多肽净含量
干品多肽的重量中不仅仅包含多肽,还包含有一些非肽的组份,如水、被吸收的溶剂、配位离子和盐等。肽的净含量是指肽在其中的重量百分比,这个百分比的数值范围很大,可能从50%到90%,取决于纯度、序列以及合成和纯化的方法,不要将肽的净含量和肽的纯度混为一谈,他们是两个完全不同的概念。纯度通常是通过HPLC测定的。纯度定义的是多肽样品中含正确序列的组分的百分比,而肽的净含量是指样品中肽类物质相对于总物质所占的百分比,肽的净含量通常是氨基酸组分分析或紫外分光法测定的,这个信息主要是在一些对肽的浓度很敏感的实验中,对计算肽的浓度是很重要的。
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