H-Ser-Ser-Met-Lys-Leu-Ser-Phe-Arg-Ala-Arg-Ala-Tyr-Gly-Phe-Arg-Gly-Pro-Gly-Pro-Gln-Leu-OH Trifluoroacetate salt
Catecholamine release-inhibitory peptide derived form chromogranin A (CHGA). Diminished expression of catestatin might increase the risk for hypertension. In Chga-/- mice rescue of elevated blood pressure to normalcy was achieved by either exogenous replacement of catestatin or transgenic expression of human Chga. Active against S. aureus and P. aeruginosa. This sequence is highly conserved across species. There are three single nucleotide polymorphisms: G364S, P370L, and R374Q. The G364S and R374Q mutants are inactive while the P370L mutant is more active than the WT. A recent study (Radek et al. Gallo, RL 2008. J Invest Dermatol 128:1525-34) established that this peptide is upregulated upon injury of skin and is part of cutaneous immune systems. It can induce mast cell migration, degranulation and production of cytokines and chemokines (Aung G et al 2011 Immunology 132:527-39). The peptide is also antioxidant, thereby preventing free radical-induced DNA damage (Mohseni S et al., 2014). Updated 9/11; 4/2014 GW. Catestatin has Antibacterial, Antifungal activity. Catestatin was found in Homo sapiens.