Recombinant G1/S-specific cyclin-E2 (CCNE2) fragment (residues 99-404) from Homo sapiens, designed for structural and biochemical studies. This 306-amino acid fragment represents a stable and soluble unit essential for cell cycle regulation at the G1/S transition, ideal for investigating mechanisms of cell proliferation.

G1/S-specific cyclin-E2, encoded by the CCNE2 gene, is critical for controlling the cell cycle during the late G1 and early S phases, as supported by multiple references (PubMed:9840927, PubMed:9840943, PubMed:9858585). It localizes to the nucleus, where it facilitates key transitions in cell division, underscoring its importance in cellular replication and potential relevance in cancer research. The selected fragment (99-404) was computationally optimized for stability and solubility, enabling detailed analysis of its functional properties without the full-length protein's complexities.