Recombinant Human CLEC12B (C-type lectin domain family 12 member B) Fragment (aa 65-276): A high-purity protein fragment encompassing the full C-type lectin domain, designed for investigating immune regulation, inhibitory signaling, and melanocyte differentiation mechanisms.

C-type lectin domain family 12 member B (CLEC12B), also known as Macrophage antigen H, is an inhibitory receptor that negatively regulates immune and non-immune functions. Upon phosphorylation, it recruits SH2 domain-containing PTPN6 and PTPN11 phosphatases via its ITIM motif to antagonize activation signals. It limits myeloid cell activation during infection or inflammation, protects target cells against natural killer cell-mediated lysis, and negatively regulates melanocyte cell cycle and differentiation through STAT3 inactivation. The protein is localized to the cell membrane as a single-pass type II membrane protein. The recombinant fragment (aa 65-276) includes the complete C-type lectin domain (aa 150-264), enabling focused