DXd Monoclonal Antibody

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  • 抗体类型:单克隆
  • 抗体来源:
  • 抗体应用:ELISA
  • 特异性:Chemical

产品详情

  • 产品名称
    DXd Monoclonal Antibody
  • 抗体类型
    单克隆
  • 抗体亚型
    Mouse IgG1, κ
  • 抗体描述
    Product has been tested in direct ELISA.
  • 抗体应用
    ELISA
  • 应用推荐
    ELISA: 1:5,000-1:20,000
  • 特异性
    Chemical
  • 制备方法
    DXd conjugated with BSA. Protein G affinity purified
  • 组分
    PBS(pH7.4), lyophilized. Reconstitution: Adding sterile water, prepare a stock solution of 2.0 mg/ml.
  • 储存方法
    Store at -20℃. Avoid freeze / thaw cycles.
  • 背景介绍
    DXd is a derivative of Exatecan (DX-8951). Dxd (Deruxtecan) is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 µM, of 10-fold potency compared to the active metabolite of irinotecan (SN-38) in vitro. Dxd has been used as the conjugated payload of the HER2-targeting ADC (DS-8201a) and some other ADCs.
  • 参考文献
    • Ogitani Y, Aida T, Hagihara K, et al. DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1Preclinical Efficacy of DS-8201a, a Novel HER2-Targeting ADC[J]. Clinical Cancer Research, 2016, 22(20): 5097-5108.
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