This product features a recombinant fragment of the human Transcription factor E4F1 (E4F1), spanning residues 434-596. This 163-amino acid fragment has been computationally designed for optimal stability and solubility, making it an ideal tool for structural studies and biochemical assays investigating E4F1's roles in transcription, cell cycle regulation, and ubiquitin ligase activity.

Transcription factor E4F1 is a multifunctional protein involved in transcriptional repression and ubiquitin ligase activity, specifically mediating ubiquitination of chromatin-associated TP53. It plays critical roles in cell survival, proliferation, and regulation of the cell cycle through the p53 and pRB tumor suppressor pathways, as well as controlling cyclin CCNA2 transcription. E4F1 also serves as a cellular target for the adenoviral oncoprotein E1A, contributing to both activation and repression of viral genes. The protein is primarily localized in the nucleus and nucleoplasm, with a small fraction detected in the