Exatecan Monoclonal Antibody

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  • 抗体类型:单克隆
  • 抗体来源:
  • 抗体应用:ELISA
  • 特异性:Chemical

产品详情

  • 产品名称
    Exatecan Monoclonal Antibody
  • 抗体类型
    单克隆
  • 抗体亚型
    Mouse IgG2b, κ
  • 抗体描述
    Product has been tested in direct ELISA.
  • 抗体应用
    ELISA
  • 应用推荐
    ELISA: 1:5,000-1:20,000
  • 特异性
    Chemical
  • 制备方法
    Exatecan conjugated with OVA. Protein G affinity purified
  • 组分
    PBS(pH7.4), lyophilized. Reconstitution: Adding sterile water, prepare a stock solution of 2.0 mg/ml.
  • 储存方法
    Store at -20℃. Avoid freeze / thaw cycles.
  • 背景介绍
    Exatecan (Exa) is a very potent inhibitor of topoisomerase I and anticancer agent. It has been intensively studied as a single agent, a large macromolecular conjugate and as the payload component of antigen-dependent antibody–drug conjugates. Exatecan (DX-8951f) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL).
  • 参考文献
    • Fontaine SD, Carreras CW, Reid RR, Ashley GW, Santi DV. A Very Long-acting Exatecan and Its Synergism with DNA Damage Response Inhibitors. Cancer Res Commun. 2023 May 24;3(5):908-916. doi: 10.1158/2767-9764.CRC-22-0517. PMID: 37377899; PMCID: PMC10208276.
    • Jo U, Murai Y, Agama KK, Sun Y, Saha LK, Yang X, Arakawa Y, Gayle S, Jones K, Paralkar V, Sundaram RK, Van Doorn J, Vasquez JC, Bindra RS, Choi WS, Pommier Y. TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor. Mol Cancer Ther. 2022 Jul 5;21(7):1090-1102. doi: 10.1158/1535-7163.MCT-21-1000. PMID: 35439320; PMCID: PMC9256811.
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