GALA is a pore-forming peptide, undergoes a pH-dependent conformational change and induces leakage of contents from large unilamellar phosphatidylcholine vesicles when in a helical conformation. GALA forms a transbilayer channel composed of 8-12 monomers.
储存指南
一般情况下, GALA 多肽 粉末应该保存在-20甚至-70摄氏度. GALA 多肽 溶解后应该-70摄氏度分装保存,避免反复冻融. 了解更多细节,请查阅手册:多肽溶解及保存指南
参考文献
Parente RA, Nir S, Szoka FC Jr. Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA. Biochemistry. 1990 Sep 18;29(37):8720-8. doi: 10.1021/bi00489a031. PMID: 2271552.