Highly active against B. subtilis, S. aureus, E. coli (MIC 0.8-7.7 uM) and moderately active against P. aeruginosa (MIC ~45 uM). Also active against C. albicans (MIC 6-7 uM) as well as cancer cells such as Hela S3, CRC SW480, and CCRF-CEMT IC50=12-35 uM (Slaninova J et al. 2012 Peptides 33:18-26). Secondary structures were determined by both CD and NMR. Numerous variants were generated to understand the sequence-activity relationships. Provided by Vaclav Cerovsky on Jannary 27, 2012. Halictine 2 has Antibacterial activity. The source of Halictine 2 is venom, the eusocial bee, Halictus sexcinctus.
Monincová L, BudesÃnský M, Slaninová J, et al. Novel antimicrobial peptides from the venom of the eusocial bee Halictus sexcinctus (Hymenoptera: Halictidae) and their analogs. Amino Acids. 2010;39(3):763-75.