Tat(l-9) is a short nonapeptide that is derived from the transactivator protein Tat of the human immunodeficiency virus-1 (HIV-1). It has been found to inhibit the activity of dipeptidyl peptidase IV (DP IV), which is a T cell activation marker. Tat(l-9) has also been shown to suppress the DNA synthesis of tetanus toxoid-stimulated peripheral blood mononuclear cells (PBMC). The paper discusses the effects of amino acid exchanges in the first three positions of Tat(l-9) and their influence on DP IV activity and PBMC proliferation.
储存指南
一般情况下, HIV-1 tat Protein (1-9) 多肽 粉末应该保存在-20甚至-70摄氏度. HIV-1 tat Protein (1-9) 多肽 溶解后应该-70摄氏度分装保存,避免反复冻融. 了解更多细节,请查阅手册:多肽溶解及保存指南
参考文献
Wrenger, S. et al. (2002). Effects of Nonapeptides Derived From the N-terminal Structure of Human Immunodeficiency Virus-1 (HIV-1) Tat on Suppression of CD26-Dependent T Cell Growth. In: Langner, J., Ansorge, S. (eds) Cellular Peptidases in Immune Functions and Diseases 2. Advances in Experimental Medicine and Biology, vol 477. Springer, Boston, MA. https://doi.org/10.1007/0-306-46826-3_18