This recombinant protein is a fragment of the human Hyaluronan mediated motility receptor (HMMR), also known as CD168, spanning residues 197-476. It represents a stable and soluble unit ideal for investigating hyaluronic acid-mediated signaling, cell motility, and metastasis-related mechanisms in structural and biochemical studies.

The full-length Hyaluronan mediated motility receptor (HMMR) functions as a receptor for hyaluronic acid and plays a critical role in cell motility. Upon binding hyaluronan, it facilitates the phosphorylation of proteins such as PTK2/FAK1 and may regulate extracellular-regulated kinase (ERK) activity, contributing to cellular transformation, metastasis formation, and adipogenesis. It is localized to the cell surface, cytoplasm, and the cytoskeletal spindle, underscoring its involvement in dynamic cellular processes and signaling pathways.