重组人BMPR2蛋白

产品详情

  • 产品名称
    重组人BMPR2蛋白
  • 蛋白种属
  • 表达宿主
    人胚胎肾细胞(HEK293)
  • Unitprot ID
  • 蛋白序列
    Met 1 - Ile 151
  • 克隆构建
    A DNA sequence encoding the human BMPR-II (NP_001195.2) extracellular domain (Met 1-Ile 151) was expressed with a C-terminal polyhistidine tag.
  • 蛋白纯度
    > 95 % as determined by SDS-PAGE
  • 分子量
    The recombinant human BMPR-II consists of 136 amino acids and has a predicted molecular mass of 15.6 kDa. As a result of glycosylation, the apparent molecular mass of rhBMPR-II is approximately 30-40 kDa in SDS-PAGE under reducing conditions.
  • 蛋白别名
    GM20272; FLJ41585; BMPR3; 2610024H22RIK; FLJ76945; BMPR-2; BRK-3; BMR2; BMPR2; T-ALK; POVD1; BMPR-II; PPH1; BMPRII; BB189135; AW546137; BMP-2; AL117858
  • 蛋白全名
    Bone morphogenetic protein receptor type-2
  • 蛋白描述
    The bone morphogenetic protein type II receptor (BMPR-II, or BMPR2), a receptor for the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) superfamily. Reduced expression or function of BMPR2 signaling leads to exaggerated TGF-beta signaling and altered cellular responses to TGF-beta. In endothelial cells, BMPR2 mutation increases the susceptibility of cells to apoptosis. BMPR2 transduces BMP signals by forming heteromeric complexes with and phosphorylating BMP type I receptors. The intracellular domain of BMPR2 is both necessary and sufficient for receptor complex interaction. It had been identified that BMPR2 plays a key role in cell growth. Its mutations lead to hereditary pulmonary hypertension, and knockout of Bmpr-II results in early embryonic lethality. The C-terminal tail of BMPR2 provides binding sites for a number of regulatory proteins that may initiate Smad-independent signalling. BMPR2 mutations were predicted to alter the BMP and TGF-b1/SMAD signalling pathways, resulting in proliferation rather than apoptosis of vascular cells, and greatly increase the risk of developing severe pulmonary arterial hypertension. BMPR2 gene result in familial Primary pulmonary hypertension (PPH) transmitted as an autosomal dominant trait, albeit with low penetrance. Heterozygous germline mutations of BMPR2 gene have been identified in patients with familial and sporadic PPH, indicating that BMPR2 may contribute to the maintenance of normal pulmonary vascular structure and function. Tctex-1, a light chain of the motor complex dynein, interacts with the cytoplasmic domain of BMPR2 and demonstrate that Tctex-1 is phosphorylated by BMPR-II, a function disrupted by PPH disease causing mutations within exon 12. BMPR2 and Tctex-1 co-localize to endothelium and smooth muscle within the media of pulmonary arterioles, key sites of vascular remodelling in PPH.
  • 发货形式
    Lyophilized from sterile PBS, pH 7.4
    1. 5 % trehalose and mannitol are added as protectants before lyophilization.
    2. Please contact us for any concerns or special requirements.
  • 内毒素
    < 1.0 EU per μg of the protein as determined by the LAL method
  • 保存条件
    Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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