重组人CD46蛋白

产品详情

  • 产品名称
    重组人CD46蛋白
  • 蛋白种属
    人
  • 表达宿主
    人胚胎肾细胞（HEK293）
  • Unitprot ID
    P15529
  • 克隆构建
    A DNA sequence encoding the Human CD46/MCP/MIC10 Cys35-Asp328 is expressed with a 6His tag at the C-terminus.
  • 蛋白纯度
    >95% as determined by SDS-PAGE.
  • 蛋白别名
    MCP; MIC10
  • 蛋白全名
    CD46 molecule(CD46)
  • 蛋白描述
    CD46 is a type I membrane protein containing four Sushi domains. CD46 is expressed by all cells except erythrocytes. CD46 has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. CD46 acts as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria.
  • 发货形式
    Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
  • 内毒素
    <1.0 EU per μg protein as determined by the LAL method.
  • 保存条件
    Lyophilized protein should be stored at <-20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
声明：本公司出售产品只能用于科研目的，不得用于诊断或者治疗！