重组人CCND3蛋白

产品详情

  • 产品名称
    重组人CCND3蛋白
  • 蛋白种属
    人
  • 表达宿主
    大肠杆菌
  • Unitprot ID
    P30281
  • 克隆构建
    A DNA sequence encoding the human CCND3 (NP_001751.1) 1-292 aa was fused with the polyhistidine tag
  • 蛋白活性
    Not tested.
  • 蛋白全名
    G1/S-specific cyclin-D3
  • 蛋白描述
    Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {PubMed:15358120}.
  • 发货形式
    Protein lyophilized in sterile PBS (58 mM Na2HPO4, 17 mM NaH2PO4, 68 mM NaCl, 100 mM GSH, pH 8.0). Trehalose (5-8%) and mannitol (5-8%) protectants were added before lyophilization.
  • 内毒素
    Please contact the lab for more information.
  • 保存条件
    Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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