Human alpha-defensin(HD-5) is a strong activity antimicrobial peptide. HD-5(1–9) treatment affects certain bacterial genera and transiently increases microbial diversity in the small intestine. Mice treated orally with HD-5(1–9) had an increased amount of Akkermansia sp. compared with nontreated mice. Moreover, in contrast to other bacteria, Akkermansia muciniphila was not susceptible to HD-5(1–9) in a turbidity broth assay. MS showed that Human Defensin-5 (1-9) had a M.W.=1029.45 dalton
储存指南
一般情况下, Human Defensin-5 (1-9) 多肽 粉末应该保存在-20甚至-70摄氏度. Human Defensin-5 (1-9) 多肽 溶解后应该-70摄氏度分装保存,避免反复冻融. 了解更多细节,请查阅手册:多肽溶解及保存指南
参考文献
Ehmann D, Wendler J, Koeninger L, et al. Paneth cell u03b1-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments. Proc Natl Acad Sci U S A. 2019;116(9):3746-3751