重组人HEPACAM蛋白

产品详情

  • 产品名称
    重组人HEPACAM蛋白
  • 蛋白种属
  • 表达宿主
    人胚胎肾细胞(HEK293)
  • Unitprot ID
  • 克隆构建
    A DNA sequence encoding the Human HEPACAM Val34-Ser240 is expressed with a 6His tag at the C-terminus.
  • 蛋白纯度
    >95% as determined by SDS-PAGE.
  • 蛋白全名
    hepatic and glial cell adhesion molecule(HEPACAM)
  • 蛋白描述
    Hepatocyte Cell Adhesion Molecule (HEPACAM) is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. HEPACAM includes a signal sequence (amino acid 1-33), an extracellular region (amino acid 34-240) with one Ig-like C2-type domain and one Ig-like V-type domain, a transmembrane segment (amino acid 241-261), and a cytoplasmic domain (amino acid 262 - 416). The cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility. HEPACAM acts as a homodimer and dimer formation occurs predominantly through cis interactions on the cell surface. HEPACAM is involved in cell motility and cell-matrix interactions. The expression of this gene is down-regulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene.
  • 发货形式
    Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
  • 内毒素
    <1.0 EU per μg protein as determined by the LAL method.
  • 保存条件
    Lyophilized protein should be stored at <-20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
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