- Unitprot ID:P24593
A DNA sequence encoding the Human IGFBP5/IBP5 Leu21-Glu272 is expressed with a 6His tag at the C-terminus.
>95% as determined by SDS-PAGE.
insulin like growth factor binding protein 5(IGFBP5)
Insulin-Like Growth Factor-Binding Protein 5 (IGFBP-5) is a secreted protein that belongs to the insulin-like growth factor (IGF) binding proteins superfamily. Members of this family prolong the half-life of the IGFs. They have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGFBP-5 contains one IGFBP N-terminal domain and one thyroglobulin type-1 domain. IGFBP-5 is expressed by fibroblasts, myoblasts and Osteosarcoma. It is also present at lower levels in liver, kidney, and brain.
Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
<1.0 EU per μg protein as determined by the LAL method.
Lyophilized protein should be stored at <-20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.