- Unitprot ID:P07237
A DNA sequence encoding the Human P4HB/ERBA2L/PDI/PDIA1/PO4DB Asp18-Lys505 is expressed with a 6His tag at the C-terminus.
>95% as determined by SDS-PAGE.
ERBA2L; PDI; PDIA1; PO4DB
prolyl 4-hydroxylase subunit beta(P4HB)
Protein Disulfide-Isomerase (P4HB) is an endoplasmic reticulum lumen protein that belongs to the protein disulfide isomerase family. P4HB contains two thioredoxin domains and catalyzes the formation, breakage, and rearrangement of -S-S- bonds in proteins. P4HB is involved in hydroxylation of prolyl residues in preprocollagen. P4HB has the ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner. P4HB plays a role in both the influx and efflux of S-nitrosothiol-bound nitric oxide.
Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
<1.0 EU per μg protein as determined by the LAL method.
Store at <-20°C, minimize freeze-thaw cycles.