Recombinant Human Interleukin-10 (IL-10) Fragment (aa 19-178) is a highly stable and soluble protein fragment engineered for advanced structural and biochemical research. This product captures the essential functional domain of IL-10, a key anti-inflammatory cytokine, offering researchers a reliable tool for studying immune regulation mechanisms.

Interleukin-10 (IL-10), also known as Cytokine Synthesis Inhibitory Factor (CSIF), is a major immune regulatory cytokine with profound anti-inflammatory functions in humans. It acts on multiple immune cells by binding to its heterotetrameric receptor (IL10RA/IL10RB), triggering JAK1 and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus to drive expression of anti-inflammatory mediators. IL-10 targets antigen-presenting cells such as macrophages and monocytes, inhibiting their release of pro-inflammatory cytokines including GM-CSF, G-CSF, IL-1α, IL-1β, IL-6, IL-8, and TNF-α. Additionally, it interferes with antigen presentation by red