IRBP (651-670) (human), sometimes referred to as hIRBP651-670 or human IRBP651-670, is amino acid residues 651 to 670 of human interphotoreceptor retinoid binding protein (IRBP), which has been identified as a new uveitogenic epitope. IRBP (651-670) (human) is uveitogenic for mice of the H-2b haplotype and elicits experimental autoimmune uveitis (EAU) with a higher severity and incidence in C57BL/6 mice than the previously characterized IRBP (1-20) (human) epitope. Co-immunization with IRBP (1-20) (human) and IRBP (651-670) human is additive but not synergistic. IRBP (651-670) (human) appears to be an epitope naturally processed from a conserved region of native IRBP.
Mattapallil MJ, Silver PB, Cortes LM, St Leger AJ, Jittayasothorn Y, Kielczewski JL, et al. Characterization of a New Epitope of IRBP That Induces Moderate to Severe Uveoretinitis in Mice With H-2b Haplotype. Invest Ophthalmol Vis Sci. 2015;56(9):5439-49