Introducing the recombinant BTB/POZ domain-containing protein KCTD17 fragment (amino acids 1-214), a high-purity tool designed for studying the BTB domain's role in ubiquitin ligase complex formation and ciliogenesis regulation. This human-derived fragment enables targeted investigation of domain-specific functions in protein degradation pathways and cellular processes.

The full-length KCTD17 protein (UniProt ID: Q8N5Z5) functions as a substrate-adapter for CUL3-RING ubiquitin ligase complexes, mediating the ubiquitination and proteasomal degradation of TCHP, a key regulator of ciliogenesis. Through this mechanism, KCTD17 positively regulates ciliogenesis and plays a crucial role in the initial steps of axoneme extension. Additionally, research suggests potential involvement in endoplasmic reticulum calcium ion homeostasis. The protein is primarily localized to the cytoplasm, where it executes its regulatory functions in protein degradation and cellular signaling pathways.