Recombinant Drosophila melanogaster Kdm4B fragment (aa 1-349) encompassing the JmjN and JmjC domains. This high-purity protein is ideal for investigating lysine-specific histone demethylase activity and epigenetic regulation mechanisms.

Probable lysine-specific demethylase 4B (Kdm4B) is a histone demethylase that specifically targets trimethylated Lys-9 and Lys-36 residues on histone H3, playing a crucial role in modifying the histone code and regulating gene expression. The enzymatic demethylation reaction produces formaldehyde and succinate as byproducts. This protein is localized to the nucleus, where it functions in chromatin remodeling and epigenetic control. The provided fragment contains the complete JmjN and JmjC domains, enabling focused studies on domain-specific demethylase function and epigenetic research.