Recombinant KIF2C (192-587) is a high-quality protein fragment derived from human Kinesin-like protein KIF2C, designed for structural and biochemical studies. This stable and soluble unit retains functional relevance, offering researchers a reliable tool to investigate microtubule dynamics and mitotic regulation.

KIF2C, also known as Mitotic Centromere-Associated Kinesin (MCAK), plays a critical role in chromosome segregation during mitosis. In complex with KIF18B, it constitutes the major microtubule plus-end depolymerizing activity in mitotic cells, regulating microtubule turnover at the kinetochore and facilitating the lateral to end-on conversion of chromosome-microtubule attachments. The protein localizes to the cytoplasm, cytoskeleton, nucleus, centromere, and kinetochore, associating with microtubule plus ends through interactions with partners like KIF18B, MTUS2/TIP150, and MAPRE1. Its centromeric localization depends on BUB1 and SGO2, underscoring its importance in ensuring accurate chromosome congression and mitotic fidelity.