LTX-315 (Synonyms: K-K-W-W-K-K-W-Dip-K-NH2) is a synthetic anticancer peptide, has the potential to adopt an amphipathic helical coil structure and was designed for intralesional treatment of tumors. LTX-315 was highly active against both murine and human melanoma cell
lines in vitro, while displaying low EC50 cytotoxic activity against human red blood cells. Furthermore, when syngeneic B16 melanomas were treated intralesionally, a majority of the animals (~80%) treated with LTX-315 experienced a complete and long-lasting tumor regression.
Camilio KA, Rekdal O, Sveinbju00f6rnsson B. LTX-315 (Oncoporeu2122): A short synthetic anticancer peptide and novel immunotherapeutic agent. Oncoimmunology. 2014