Recombinant Human Nucleotidyltransferase MB21D2 (EC 2.7.7.-), encompassing amino acids 1-431, is a high-purity protein fragment designed for structural and biochemical studies. This product captures a stable, soluble unit of MB21D2, enabling researchers to investigate its role in cyclic dinucleotide synthesis and signaling pathways.

MB21D2, encoded by the gene MB21D2 in Homo sapiens, is a probable nucleotidyltransferase that catalyzes the formation of cyclic dinucleotide second messengers in response to unknown stimuli. These cyclic dinucleotides are critical signaling molecules involved in immune responses and cellular communication, as supported by research (PubMed:34261127). The recombinant fragment (1-431) was selected computationally to ensure stability and solubility, facilitating experimental analysis of its enzymatic activity and structural properties.