Recombinant Human MDM2 (1-111) Fragment: A high-purity recombinant protein encompassing the SWIB/MDM2 domain (residues 26-109) of E3 ubiquitin-protein ligase Mdm2. This fragment serves as an essential tool for studying the specific molecular functions of this critical regulatory domain involved in p53 pathway modulation and protein-protein interactions.

MDM2 (E3 ubiquitin-protein ligase Mdm2) is a crucial regulatory protein primarily known for its role as a negative regulator of the tumor suppressor p53. As a RING-type E3 ubiquitin transferase, MDM2 mediates the ubiquitination of p53, leading to its proteasomal degradation, thereby inhibiting p53-mediated cell cycle arrest and apoptosis. Beyond its canonical p53 regulation, MDM2 exhibits diverse functions including self-ubiquitination, ubiquitination of ARRB1, promotion of nuclear export of p53, and proteasome-dependent degradation of retinoblastoma RB1 protein. The protein localizes predominantly to the nucleoplasm but also shows cytoplasmic and nuc