Recombinant Human Podocalyxin Fragment (aa 341-461) is a highly stable and soluble protein segment designed for structural and biochemical studies. This fragment, derived from the full-length Podocalyxin protein involved in cell adhesion, morphology regulation, and cancer progression, offers an optimal tool for investigating key molecular mechanisms in cellular dynamics and disease research.

Podocalyxin, encoded by the PODXL gene, plays a dual role in regulating cell adhesion and morphology, contributing to processes such as maintaining filtration pathways in podocytes and enhancing cell migration and invasion in cancer. It localizes to apical cell membranes, microvilli, lamellipodia, and membrane rafts, where it interacts with actin-binding proteins like EZR to influence MAPK and PI3K signaling pathways. This protein is critical in epithelial polarization, lumen formation during renal tubulogenesis, and cancer aggressiveness, making it a significant target for studies in cell biology and oncology.