Recombinant Human Peptidyl-prolyl cis-trans isomerase A (PPIase A) fragment (amino acids 1-165) is a high-purity protein encompassing the complete PPIase cyclophilin-type functional domain. This fragment retains the catalytic activity for cis-trans isomerization of proline imidic peptide bonds and serves as an essential tool for investigating enzymatic mechanisms, signal transduction pathways, and protein interactions in cellular processes.

Peptidyl-prolyl cis-trans isomerase A (PPIase A), also known as Cyclophilin A, is a multifunctional enzyme encoded by the PPIA gene in humans. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and plays critical roles in leukocyte chemotaxis, endothelial cell activation, apoptosis regulation, and platelet aggregation. The protein modulates key signaling pathways, including NF-kappa-B, MAPK/ERK, and AKT1, and is involved in oxidative stress responses. It also interacts with viral proteins, such as those from influenza A virus