This recombinant protein is a 198-amino acid fragment of human Prostamide/prostaglandin F synthase (PRXL2B), representing a stable and soluble unit ideal for structural studies and biochemical characterization of its catalytic activity in prostaglandin metabolism.

Prostamide/prostaglandin F synthase, encoded by the PRXL2B gene, functions as a key enzyme in lipid mediator biosynthesis. It specifically catalyzes the reduction of prostamide H₂ to prostamide F₂α using NADPH as a proton donor, and also converts prostaglandin H₂ to prostaglandin F₂α. These reactions position the enzyme as a significant regulator in prostanoid signaling pathways. The full-length protein is localized to the cytoplasm and cytosol, where it participates in intracellular metabolic processes. This fragment encompasses the complete functional domain (residues 1-198), providing researchers with a valuable tool for investigating the enzyme's mechanism and potential therapeutic applications.