Lactoferrin is one of a number of multifunctional proteins that are present in or on all mucosal surfaces throughout the body. Lactoferrin is an antimicrobial lipopolysaccharide (LPS)-binding protein. Lf(28-34)/RKVRGPP derived from the N terminus of lactoferrin, has been identified as LPS-binding sites (binding to lipid A).
Fine DH. Lactoferrin: A Roadmap to the Borderland between Caries and Periodontal Disease. J Dent Res. 2015 Jun;94(6):768-76. doi: 10.1177/0022034515577413. Epub 2015 Mar 17. PMID: 25784250; PMCID: PMC4485328.
Elass E, Masson M, Mazurier J, Legrand D. Lactoferrin inhibits the lipopolysaccharide-induced expression and proteoglycan-binding ability of interleukin-8 in human endothelial cells. Infect Immun. 2002 Apr;70(4):1860-6. doi: 10.1128/IAI.70.4.1860-1866.2002. PMID: 11895948; PMCID: PMC127826.