S-PE is a peptide(sequence: PCRFFESHVA) with active stem cell recruitment capacity. S-PE was screened and identified on Discovery Studio software through peptide display techniques. S-PE showed a outstanding cell homing effect with bone marrow mesenchymal stem cells (BMSCs), as well as promoted osteogenic differentiation to some extent, since S-PE is a promising target peptides simulating the functional domain of stromal cell-derived factor-1 (SDF-1).
Zhi Peng, Shiwei Niu, Li Gui, Xiaolin Kuang, Fan Li, Bo Chen, Wanting Li, Jianlin Jiao, Sheng Lu, Di Lu, Wnt3a loaded deformable hydrogel acts as a 3D culture platform for in situ recruitment of stem cells to efficiently repair bone defects via the asymmetric division, Chemical Engineering Journal, Volume 442, Part 1, 2022, 136163, ISSN 1385-8947, https://doi.org/10.1016/j.cej.2022.136163.