This product is a recombinant fragment of Sentrin-specific protease 5 (SENP5), spanning residues 493-755, derived from Homo sapiens. It represents a stable and soluble unit optimized for structural and biochemical studies, supporting research into SUMO pathway regulation and cellular division mechanisms.

Sentrin-specific protease 5 (SENP5) is a crucial enzyme in the SUMO pathway, responsible for processing full-length SUMO3 to its mature form and deconjugating SUMO2 and SUMO3 from target proteins. While it exhibits weak activity toward SUMO1, its functions are essential for proper cell division. SENP5 is localized primarily in the nucleus and nucleolus, underscoring its role in nuclear processes. This fragment, selected for stability and solubility, enables detailed investigation of SENP5's biochemical properties without the complexities of the full-length protein.