Recombinant Human Signal-transducing Adaptor Protein 2 (STAP-2) Fragment (residues 1-247) is a high-purity protein designed for studying the pleckstrin homology (PH) domain and its regulatory roles in inflammation and STAT3 signaling pathways. This fragment serves as an essential tool for kinase assays, protein interaction studies, and functional investigations.

Signal-transducing Adaptor Protein 2 (STAP-2), also known as Breast Tumor Kinase (BRK) substrate, is a cytoplasmic protein involved in modulating the acute-phase response during systemic inflammation. It functions as a substrate for protein kinase PTK6 and plays a regulatory role in STAT3 activity, contributing to inflammatory signaling mechanisms. The full-length protein is localized in the cytoplasm, where it mediates key signal transduction events relevant to immune responses and cellular regulation.