H-RFC*WKVC*YKGIC*FKKC*K-NH2 (C3-C16 and C7-C12 disulfide bonds)
三字母序列
H-Arg-Phe-Cys-Trp-Lys-Val-Cys-Tyr-Lys-Gly-Ile-Cys-Phe-Lys-Lys-Cys-Lys-Amidation (C3-C16 and C7-C12 disulfide bonds)
长度 (aa)
17
多肽纯度 (HPLC)
95.2
分子式
C99H155N27O18S4
分子量
2135.70
来源
固相合成
其他信息
Tachyplesin 1 (TP1; 1) is an antimicrobial peptide extracted from hemocytes of the Japanese horseshoe crab Tachypleus tridentatus.
Tachyplesin I displayed a potent activity against marine vibrios, with a MIC of 0.4-0.8 μg/ml against Vibrio P1.
It is highly hemolytic against mammalian erythrocytes, which precludes it from further development.
Edwards, Ingrid A et al. “Contribution of Amphipathicity and Hydrophobicity to the Antimicrobial Activity and Cytotoxicity of β-Hairpin Peptides.” ACS infectious diseases vol. 2,6 (2016): 442-450.
Edwards IA, Elliott AG, Kavanagh AM, Blaskovich MAT, Cooper MA. Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. ACS Infect Dis. 2017 Dec 8;3(12):917-926. doi: 10.1021/acsinfecdis.7b00123. Epub 2017 Oct 3. PMID: 28960954.