重组人TNFRSF12A蛋白

人

人胚胎肾细胞（HEK293）

Glu 28 - Trp 79

A DNA sequence encoding the human TNFRSF12A isoform 1 (Q9NP84-1) extracellular domain (Glu 28-Trp 79) was fused with the Fc region of human IgG1 at the N-terminus.

> 95 % as determined by SDS-PAGE

Immobilized Cynomolgus mFc-TNFSF12 (Cat:502405) at 10 μg/ml (100 μl/well) can bind human Fc-TNFRSF12A, The EC₅₀ of human Fc-TNFRSF12A is 0.07-0.15 μg/ml.

The recombinant human TNFRSF12A/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 313 amino acids and has a calculated molecular mass of 34 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhTNFRSF12A/Fc monomer is approximately 37 kDa.

TWEAKR; FGF-INDUCIBLE 14; FN14; TWEAK-R; TWEAK-RECEPTOR; TYPE I TRANSMEMBRANE PROTEIN FN14; FIBROBLAST GROWTH FACTOR REGULATED PROTEIN 2; HPIP; CD266; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 12A; FIBROBLAST GROWTH FACTOR-INDUCIBLE IMMEDIATE-EARLY RESPONSE PROTEIN 14

Tumor necrosis factor receptor superfamily member 12A

Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.

Lyophilized from sterile PBS, pH 7.4
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

< 1.0 EU per μg of the protein as determined by the LAL method

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.