This product offers a recombinant fragment of human Thioredoxin-interacting protein (TXNIP), spanning amino acids 1-298. This stable and soluble fragment is ideal for structural studies, biochemical assays, and functional investigations related to oxidative stress regulation, cell cycle control, and tumor suppression pathways.

Thioredoxin-interacting protein (TXNIP) is a multifunctional protein involved in oxidative stress mediation by inhibiting thioredoxin activity, thereby limiting its bioavailability. It acts as a transcriptional repressor and plays a critical role in inducing G0/G1 cell cycle arrest. TXNIP also functions as a tumor suppressor by inhibiting cell growth and contributes to mTORC1 regulation through stabilization of DDIT4. Additionally, it is essential for natural killer cell maturation and interacts with proteins like COPS5 to influence CDKN1B stability. The protein localizes to both the cytoplasm and nucleus, reflecting its diverse regulatory roles in cellular processes.