重组狗IL11RA蛋白
- 蛋白种属:狗
- 表达宿主:人胚胎肾细胞(HEK293)
- Unitprot ID:E2RAD9
产品详情
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产品名称
重组狗IL11RA蛋白
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蛋白种属
狗
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表达宿主
人胚胎肾细胞(HEK293)
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Unitprot ID
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蛋白序列
Met 1 - Leu 363
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克隆构建
A DNA sequence encoding the canine IL11RA (XP_005626799.1) (Met1-Leu363) was expressed with a C-terminal polyhistidine tag.
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蛋白纯度
> 90 % as determined by SDS-PAGE
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分子量
The recombinant canine IL11RA comprises 352 amino acids and has a predicted molecular mass of 38.4 kDa. The apparent molecular mass of the protein is approximately 47.7 kDa in SDS-PAGE under reducing conditions.
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蛋白别名
IL11RA; AI314697; MGC2146; IL11RA2; RP23-167I12.2; IL11RA1; HCG_2011440; IL-11RA; NR1; GP130
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蛋白全名
Uncharacterized protein
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蛋白描述
Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus, and three variants encoding two different isoforms have been identified. IL11RA/IL-11RA is a receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. Defects in IL11RA/IL-11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly.
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发货形式
Lyophilized from sterile PBS, pH 7.4.
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.
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内毒素
< 1.0 EU per μg of the protein as determined by the LAL method
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保存条件
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
重组蛋白定制服务:
纽普生物(NovoPro)提供大肠杆菌、哺乳细胞、昆虫细胞和酵母细胞重组蛋白定制服务
声明:本公司出售产品只能用于科研目的,不得用于诊断或者治疗!