Recombinant YEATS2 (204-332) Fragment is a high-quality, soluble protein derived from the human YEATS domain-containing protein 2. This fragment is ideal for investigating chromatin regulation, specifically histone recognition and modifications, in structural and biochemical studies.

The full-length YEATS2 protein is a chromatin reader component of the ATAC complex, which possesses histone acetyltransferase activity targeting histones H3 and H4. It specifically binds to histone H3 crotonylated at Lys-27 (H3K27cr), a modification associated with active promoters and enhancers that confers resistance to transcriptional repressors. YEATS2 is localized in the nucleus, where it plays a critical role in epigenetic regulation and gene expression control.