Recombinant YEATS4 (YEATS domain-containing protein 4) fragment encompassing the complete YEATS domain (amino acids 1-227). This high-purity recombinant protein serves as an essential tool for studying chromatin recognition mechanisms, specifically investigating the YEATS domain's role in binding acylated histone H3 modifications and its function within the NuA4 histone acetyltransferase complex.

YEATS4 (also known as Gas41 or NuBI-1) is a crucial chromatin reader component of the NuA4 histone acetyltransferase complex, which plays a fundamental role in transcriptional activation through acetylation of nucleosomal histones H4 and H2A. The protein specifically recognizes and binds acylated histone H3, demonstrating preferential binding to histone H3 diacetylated at Lys-18 and Lys-27 (H3K18ac and H3K27ac) or Lys-14 and Lys-27 (H3K14ac and H3K27ac), and also recognizes crotonylated histone H3. YEATS4 is localized to the nucleus and plays a key role in histone variant H2AZ1/H2A.Z deposition into specific